3D Bioprinting – How is the Future of the Healthcare Industry Panning Out?

The people who are working in the field of 3D Bioprinting are making new development with every passing day, in the technology as well as in their compression of how it can be put to best use in the real world.

Defining Bioprinting?

The process of 3D bioprinting is an additive manufacturing that makes the use of cells and additional biocompatible materials like “inks”, also called bio-inks, for printing living structures adding on layer-by-layer which mimics the behavior of natural living systems.

This process is more and more used for pharma development and validation of drugs, and in the forthcoming times will be employed for medical applications in clinical surroundings, 3D printed skin grafts, implants, bone grafts, biomedical devices, and even complete 3D printed organs, are all hot topics of bioprinting research.

The Present and Future of 3D bioprinting

Right now, the bioprinting of entirely functional composite internal organs, like heart, kidneys, and livers, is still a decade away as a minimum from being a reality but advancements are taking place in this regard at a rapid rate as a result of current accomplishments in clinical research.

A system of cells, nerves, tissues and structures in a human organ needs to be suitably located with a lot of precision for functionality. From positioning the numerous tiny capillaries in a liver, to printing a heart that beats exactly like a normal heart, it is a hard process which will take a whole lot of time.

While some human body parts are more intricate than others, each piece has its peculiar necessities and issues that require addressing. The assortment of the cell types, accurate materials, and bio-inks must be as accurate just as the blueprint

Furthermore, when one wants to work through all these complexities, it requires the incorporation and input of a number of cutting-edge technologies from more than a few fields like engineering, science, biomaterials, physics, cell biology, and medicine.

Difficult But Opportune Way Ahead

Contempt all these difficulties, the process of bioprinting is quickening at a rapid rate and it is a time, when this field is seeing a lot of potential. The people who are working heart out in are putting their best foot forward in the technology as well as and comprehending that how it can be used for getting the best possible results. While we are still not anywhere close to the product, there is still no doubt in the fact that the future of medicine and healthcare will be pretty different in the years to come, all thanks to the process of bioprinting.

With a high need for organ transplants in the world, increased drug delivery activities and growing elderly population around the world, the demand for 3D bioprinting will reach to a value of about$5,873 million by the year 2030.

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3D Bioprinting Finding Increasing Usage in Stem Cell Culture

As per government sources, more than 107,000 people in the U.S. were waiting for an organ transplant in February 2021. Moreover, last year, merely 39,000 such surgeries were performed in the country. Due to such a staggering difference in the number of those who need organ transplants and those who ultimately get it, 17 people die each year in waiting. The reasons are aplenty; despite campaigns and awareness programs by government and international organizations, such as the United Nations (UN) and World Health Organization (WHO), not many are willing to donate their organs.

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For 3D bioprinting, the shape and size of the organ to be replaced inside the patient are obtained via a computed tomography (CT) or magnetic resonance imaging (MRI) scan. Thereafter, the scan is fed to computer-aided design (CAD) software for printing a 3D model. This is followed by the preparation of the bioink, which is essentially living cells mixed with a base like gelatin, collagen, silk, hyaluronan, nanocellulose, and alginate, which nourishes the cells and keeps them alive. Finally, the 3D model is broken into extremely thin layers by slicer software, which commands the 3D printer to create the organ from the bioink.

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Another significant application of 3D bioprinting is cell culture, especially those of stem cells. Stem cells obtained from the ovaries, fetuses, embryos, and adults can differentiate themselves into many types of cells, tissues, and even complete organs, which is another way in which the dearth of transplantable organs can be addressed. For this purpose, 3D bioprinting is helping in the culture of stem cells with high throughput, for regenerating tissue. The bioink used in 3D printers is now being laden with stem cells, so that the desired tissue or organ can be created.

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