RNA sequencing revolutionizes the transcriptome study. It involves a highly sensitive and accurate tool for measuring transcriptome expression. It provides scientists to visualize the previously undetected changes in disease formation, concerning therapeutics in various environmental conditions and a wide range of study designs.
RNA sequencing facilitates the researchers to detect novel and known features in a single assay, facilitating the detection of gene fusions, transcript isoforms, single nucleotide variants, and other features.
RNA expression reflects the effects exerted by DNA on the cell. The mature mRNA consists of coding sequences of all expressed genes. RNA also serves as a principal DNA substitute in numerous diagnostic applications.
As DNA is more stable, DNA-based diagnosis is highly preferred. RNA analysis is crucial in various applications of molecular diagnostics. Moreover, RNA analysis is widely used in RNA virus detection and quantification, including hepatitis C virus, and HIV. It holds great prominence in the detection of cancer. As it serves as a crucial tool for the tumor’s molecular stratification.
The RNA analysis industry has garnered $14,909.8 million revenue in 2021, and it is projected to advance at the rate of 13.3% from 2021 to 2030, to generate $14,909.8 million revenue in 2030.
RNA sequencing utilizes the capability of high-throughput sequencing methods to offer insight into cell transcriptome. Moreover, RNA sequencing provides closer analysis and greater transcriptome resolution. The RNA-sequencing data enables novel transcripts discovery, identifies alternatively spliced genes, and detects the allele-specific expression.
The RNA-sequencing workflow advancements from sample preparation to library construction, and data analysis facilitate the sample preparation to data analysis and library construction. It helps researchers to elucidate the transcription’s functional complexity.
The RNA-sequencing can be applied to identifying the various RNA populations, such as pre-mRNA, total RNA, and noncoding RNA, including long ncRNA and microRNA in polyadenylated messenger mRNA transcripts.
In several instances, cancer cells with specific chromosomal translocations can be detected with higher sensitivity with mRNA analysis.
The development of advanced technologies such as SMaRT technology, antisense technology, and RNA interference technology is projected to provide opportunities to companies providing RNA-based therapies and vaccines in the coming years.
Advantages of RNA Sequencing
• The next generation RNA-sequencing is a preferred method of choice for scientists to study the transcriptome.
• It facilitates precise and sensitive gene expression measurement.
• RNA sequencing captures both novel and known features, without any need for required predesigned probes.
• It reflects the whole transcriptome, not only a few selected transcripts.
• RNA sequencing can be applied to any species, even in the absence of a reference sequence.
The major players operating in the industry are, Merck KGaA, Agilent Technologies Inc., Eurofins Scientific SE, Fluidigm Corporation, Danaher Corporation, F.Hoffmann-La Roche Ltd., and Illumina Inc.
Therefore, the rising prominence of RNA analysis in healthcare boosts its demand.
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