Skin Replacement and Substitutes Market to Witness Robust Growth in Coming Years

 Over 180,000 people are burned to death every year, the World Health Organization (WHO) had estimated in 2018. Additionally, burns are the leading cause of disability-adjusted life years (DALY) in low- and middle-income countries. Such incidents often lead to nasty scars, as the skin peels or melts. In severe cases, the skin is damaged so much that it is unable to heal or grow back on its own, which results in skin grafting procedures.

Thus, with the increasing incidence of burn injuries, the skin replacement and substitutes market, which valued $838.0 million in 2018, is predicted to grow to $1,202.2 million by 2024, at a CAGR of 6.3% during 2019–2024 (forecast period). The usage of such products helps close and mend the wound as well as reduce the pain, which is why they are witnessing a rising adoption around the world. There are two primary types of skin replacement and substitute products available — cellular and acellular — of which the acellular variants are more in demand, as they can be used for excised and superficial wounds, even in pediatric patients. 

All the cellular and acellular products are further segregated as class I, II, and III. Of these, class III products account for the widest adoption, as they can effectively mend the dermis as well as the epidermis, which makes them suitable for ulcers, burns, and numerous other kinds of wounds. Ulcers, in particular, can result in the loss of the entire epidermal layer, as well as the dermal layer and subcutaneous fat, in severe cases. If left untreated, skin ulcers can morph into full-blown gangrene, the treatment for which is amputation, which is why an increasing number of people are seeking treatment for them. 

Another reason for the rising demand for such products is the growing disposable income of people around the world. According to the World Bank, the worldwide gross domestic product (GDP) per capita surged from $8,820.013 in 2009 to $11,312.555 in 2018. This rising purchasing power is enabling people to spend more on their appearance, which is why they are rapidly going for dermatological treatments, even if they are lot life-threatening, thereby leading to the surging demand for skin replacement and substitute products. 

Therefore, with more people suffering from burns and skin diseases, the demand for products which help treat the wounds will also increase. 

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How is Rising Incidence of Burn Injuries Contributing in Skin Replacement and Substitutes Market Growth?

A World Health Organization (WHO) study presented the statistics regarding burn injuries in 2018, which mentioned that every year, about 180,000 people succumb to burn injuries, with majority of the incidents occurring in low- and middle-income countries. Additionally, burns are considered to be among the leading causes of disability-adjusted life years in these countries. One example is of India where more than 1,000,000 people suffer from moderate to severe burn injuries every year. Furthermore, in nations, such as Pakistan, Egypt, Colombia, and Bangladesh, about 18% children become permanently differently abled and about 17% become differently-abled due to burn injuries.

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As these injuries result in extensive skin damage, one of the most important ways to treat them is to use the skin replacement and substitutes. These are referred to as a skin graft, for which, the skin is collected from a suitable site and then transplanted on to the affected area of the recipient’s body. This is done to encourage the regeneration of the affected tissue and the formation of new functional skin. These substitutes are majorly available as cellular and acellular products.

During 2014–2018, acellular skin replacement and substitutes were the most popular. In fact, in the coming time as well, they would continue to witness the highest demand. These products consist of acellular components, such as collagen or nylon mesh, which act as a silicon membrane and a dermis. Further, they contain biological matrix and biologically-processed matrix. Besides being suitable for skin replacement in pediatric population, these products can be used to treat superficial as well as excised wounds. A P&S Intelligence study has predicted the skin replacement and substitutes market to advance at a 6.3% CAGR in the coming years.

With the increasing knowledge about medical sciences, it has been established that the skin grafts taken from one individual, when administered into the other, may trigger a fatal immune response. To take care of this, extensive research has been going on in the biomedical field for the development of bio-engineered skin. One of the methods that have been effective in skin regeneration is by using skin scaffolds, which are essentially 3D structures that are seeded with keratinocytes and placed at the wound site. This would help in providing protection against microorganisms, toxins, and other harmful agents. Some popular products that have already been developed and market are Dermagraft, Transcyte, and AlloDerm.

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