How is the Sample Prepared for Next Generation Sequencing?

The process of next-generation sequencing has been there for approximately twenty years old and is a much higher quantity analysis process for DNA sequencing than the preceding sequencing methods which first appeared in the year 1977.

There are more than a few definite steps involved in getting samples ready for next-gen sequencing, which will be talked about in this blog.

Sample assortment and storage

The initial step in any experiment of DNA sequencing is the procurement of samples. The moment samples have been collected; it is significant to preserve these constituents. CellCover functions as a cell fixation tool that liquid freezes samples with the aim of performing downstream analyses on tissue, proteins, RNA, and DNA. Subsequently, cells fixed with CellCover, samples can be examined with the use of a range of a variety of methods like DNA FISH, microarray, single-cell sequencing, immunostaining, or high data analysis of DNA by means of next-gen sequencing. Cell fix is a significant step in preserving the quality of the samples for getting excellent results.

DNA Extraction and Amplification

With the purpose of performing DNA sequencing on the samples, DNA must now be taken out from the preserved tissue or cells. There are quite a few kits offered in the market which attain this, numerous of which can be automated to decrease active time.

If the execution of a single-cell RNA sequencing experiment, cells should be secluded before the process of DNA extraction. Single-cell sequencing usually necessitates unique cells be designated for distinct high throughput analysis.

Library Preparation

The minute DNA has been taken out and optionally augmented; quite a lot of library preparation phases take place to make the sample for Next Gen Sequencing.

“On the whole, the core steps in making RNA or DNA for NGS examination are: (i) dividing and/or sizing the target arrangements to an anticipated length

 (ii) translating the target to double-stranded DNA,

 (iii) ascribing oligonucleotide adapters to the ends of for targeting fragments

 (iv) quantitating the ultimate library product for sequencing.

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Increasing Elderly Population Call for More Spinal Treatments

In 2021, the interbody spine implants market was valued at $1,904.8 million and will reach $2,471.8 million by 2030, growing at a rate of about 3% during the forecast period. The major factors responsible for the development of the market are the improvements in the technologies of spine surgery, an increase in demand for devices for spinal fusion because of the surge in the incidence of spinal ailments, rapid acceptance of minimally invasive surgeries for the spine, and surge in the introduction of innovative bone-grafting products.

It is given that spinal issues are more common in elderly people than in adolescents or youngsters. A rapid growth in the elderly population all over the globe, and especially in the Asian subcontinent will add up to the demand for interbody spinal implants.  The elderly population of India will touch 194 million in the year 2031 from 138 million in 2021, a 41% increase will be experienced over the next ten years as per a report of the NSO

The volume of patients having from spine disorders is rising at a global level. For treating these conditions doctors need cutting-edge implants and technologies. Some of the key ailments treated with the use of spine implants include scoliosis, degenerative disc disease, spondylolisthesis, fracture, and kyphosis.  As per a study of the NLM, more than 266 million people have lumbar DSD every year. This enormous population having spine disorders intensifies the requirement for interbody spine implants.

The metal-based implants will have the highest demand of over 45% in the interbody spine implants market and will have the highest growth rate in the years to come. This has a lot to do with the high usage of metal-based implants in spine surgeries, because of their durability, suppleness, and robustness. Apart from that, these comprise metals like stainless steel, tantalum, and titanium. Asa per the AAOS, most spinal implants are made with a combination of titanium alloys, pure titanium, and stainless steel.

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The Future of Endodontic Devices

Endodontic operations are frequent yet specialized procedures carried out in several conventional dental clinics that only focus on endodontics. These treatments address patients whose teeth have root-related issues and demand a variety of equipment made especially for each stage of a root canal surgery.

In 2021, the endodontic devices market accounted for $1,492.0 million worth, which will reach $2,283.4 million value by 2030. The rise in dental infections is mostly to blame for the industry's expansion. The need for endodontic devices is expected to increase in the upcoming years due to the increase in dental tourism activities.

These tools are made to make root canal procedures more efficient and comfortable for both the patient and the dentist. While endodontic files and broaches are primarily used for sculpting the canals, a variety of other endodontic devices are used during root canal procedures.

Due to advancements in delivery systems, that have given dentists several benefits such as simple handling and moving of handpieces during operations, the instruments category, which currently leads the endodontic devices market, is predicted to generate $1,206.7 million revenue in 2030.

Technically advanced tools have a variety of tip types based on form, composition, and length, such as ultrasonic equipment. Additionally, the frequency and intensity of the vibrations produced by the tip in use may be managed with the use of ultrasonic equipment. For example, Kerr Corporation provides a variety of specialty tips, including microsurgical ultrasonic tips with a diamond coating that is intended for endodontic microsurgery.

Although stainless steel hand files have been used almost solely for a long time to prepare canals, these tools might result in steps, deviations, and canal perforations because of their high stiffness and poor flexibility. Rotary Nickel-Titanium (NiTi) tools were brought to the industry to reduce problems and address anatomical difficulties associated with root canal procedures.

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Endoscope Reprocessing Market To Advance at a Growth Rate of around 10%

The size of the endoscope reprocessing market at around $1,880 million in 2021, which is expected to reach about $4,358 million by 2030, advancing at a growth rate of about 10% in the years to come. This is due to the rising inclination toward MIS procedures, the propagating risk of numerous infections related to soiled endoscopes, and the surging strict government regulations spanning all around the globe to control these infections.

The high-level disinfectants and test strips have approximately 35% of the market share in the endoscope reprocessing market in 2021, because of the rising occurrence of numerous endogenous infections like pneumonia and, bacteremia after the usage of endoscopy processes. Similarly, the acceptance of test strips is also growing for the effective measurement of MEC required for high-level decontamination, thus providing faster disinfection reaction time.

Endoscope reprocessing is mainly used in flexible endoscopes, having a higher revenue share of approximately 65% in 2021 in the endoscope reprocessing market. This is since prominent companies are launching AERs that are highly compatible with supple endoscopes. For example, around 90% of corporations are evolving AERs for flexible endoscopes, because of their viability to control and lightweight.

Users are more inclined toward entering into inclusive contracts with ISOs, with the intention of reducing difficulties and further expenses allied with discrete services provided under agreements with producers of medical apparatus. For example, NovaMed Corporation runs a comprehensive service management program that permits clienteles to combine the company’s services into one contract. The contract delivers a lucrative alternative to OEM contracts, in addition to multi-modality and multi-vendor access. Such instances confirm that the acceptance of inclusive endoscope service contracts is snowballing.

The APAC endoscope reprocessing market will have the highest growth rate, over 10%, because of the surge in the count of endoscopic surgeries and the upgrading in healthcare infra. Additionally, China and Japan collectively had approximately 50% share in 2021. This is because of the high frequency of GI-related cancers in both nations. For example, to a government company, there were approximately 3,00,000 GI-related deaths with cancer in the People’s Republic in the year 2021, which has in excess of 13% of all cancer-related deaths in the nation.

With the increasing number of MIS procedures in the people, there is an increase in the demand for endoscope reprocessing instruments.

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High Demand for Electric Rickshaw Batteries Led by Increasing Traction of Vehicles Due to Low Running Cost

 Do you have ever experienced traveling on e-rickshaws? It is a convenient travel mode in metro cities to cover short distances. The nine to five workforces heavily rely on e-rickshaws to reach the metro stations at their nearby location. It is quite common to see people with office bags in the morning looking for e-rickshaws to reach metro stations, and from metro stations to reach offices. It goes the same during evenings they take e-rickshaws from nearby office locations to reach metro stations, and after their metro travel, they further take e-rickshaws to reach home.

Inexpensive Cost of E-Rickshaws

Instead of picking motor vehicles to cover such short distances, e-rickshaws are massively encouraged as a convenient travel facility. There are numerous benefits of this transport. It is extremely cheap as compared to auto-rickshaws, which can sufficiently accommodate two passengers. An e-rickshaw cost amount from Rs. 60 thousand to Rs. 1.1 lakhs, while an auto-rickshaw costs between Rs. 1.5 lakhs to Rs. 3 lakhs.

Employment Generation By E-Rickshaws

The e-rickshaws usually experience fewer maintenance issues, and hence save cost. Along, with this, the rising popularity of this travel service provides employment to a large number of people. The cycle-rickshaw drivers are massively shifting toward e-rickshaws due to higher convenience and rising preference for this travel service over cycle-rickshaws. The running cost of e-rickshaws for a distance of 2.1 to 2.3 km is only Rs. 0.4.

Environment Benefits of E-Rickshaws

The e-rickshaw pose numerous environmental benefits. It includes alleviating air and noise pollution caused by transport. Around 1,036.6 tonnes of carbon dioxide emissions can be eliminated by replacing CNG auto-rickshaws with e-rickshaws.

Government Initiatives Driving E-Rickshaw Sales

Moreover, the government initiatives encourage e-rickshaw traction. It includes National Electric Mobility Mission, 2013, FAME I and II, Pradhan Mantri Mudra Yojana, 2015, and National Urban Livelihood Mission 2013. Along with these initiatives, the electric vehicle policy of the state in the forms of loans, direct subsidies, and regulatory framework also supports the rising adoption of the e-rickshaws.

Increasing Sales of Electric Rickshaws Batteries 

In 2021, the sales of e-rickshaw batteries contributed $141.3 million in revenue and are expected to rise to $295.4 million by 2030, advancing T ~8.5% rate from 2021 to 2030. Most of the e-rickshaws sales go unregistered due to their rising popularity and unorganized manufacturing companies. Presently, the registered sales of e-rickshaws account for 15,00,000, with an additional sale of 11,000 new e-rickshaws every month.

The unorganized players sell around 10,000 e-rickshaws per month, while organized players monthly contribute to sales of 1,500 to 2,000 e-rickshaws. E-rickshaws run on electric charge provided by batteries, and hence increasing adoption of e-rickshaws lead to rising sales of electric rickshaw batteries.

Rising Preference for Li-ion Battery 

There are usually two types of batteries used in electric rickshaws, li-ion battery, and lead-ion battery. Li-ion batteries have a higher preference over the lead-ion battery. It is due to their high capacity, lightweight, and availability in industry sizes. The low-discharge rate of lithium-ion batteries supports the maintenance of charge for a longer duration. It can get completely charged within 1 to 3 hours.

Therefore, the inexpensive running cost and high convenience offered by e-rickshaws for short-distance travel, including government initiatives drive the sales of e-rickshaws in India.

Get More Details India Electric Rickshaw Battery Market Demand and Business Opportunities 

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Can applying AI to genomics improve healthcare?

Biology's interdisciplinary field of genomics focuses on understanding the composition, mapping, organization, and altering of genomes. A genome is an organism's whole set of DNA, which contains every gene. In addition, there are numerous R&D initiatives, businesses in the sector, and growing genomics research data sets.

Functional Genomics - in this field, scientists try to explain how genes interact and carry out their roles. Making promoters and enhancers, identifying subcellular localization, and classifying functional activity mutations are all possible uses for machine learning.

Structural Genomics – Here, scientists investigate the characterization of genomic structures. Protein tertiary structure may be categorized by machine learning, and linkages between protein secondary structures can also be made.

Regulatory Genomics – is the study of genetic traits and expression-control mechanisms. For instance, applications of machine learning in this field include categorizing gene expression predictions, creating transcription aspects and RNA-binding proteins, or utilizing ML techniques to predict promoters and modifiers for gene expression.

Role of AI in Genomics

One of the most cutting-edge areas of genomics is AI, which simplifies data processing and deep learning to speed up research. AI systems may progressively learn about topics and create algorithms using deep learning and neural networks after being trained by analyzing volumes of human-reviewed data.

In contrast to human input, this enables AI to process a higher volume of data, improving its capacity to decipher trends and predict events. Some instances where the pattern recognition capabilities of a trained AI network may be used demonstrate the power of AI-driven genomics. To help with the diagnosis of cancer and genetic disorder diagnosis, genomic analysis systems and computer vision algorithms have been combined.

Therefore, the global ai in the genomics market will hit a $19,596.2 million value by 2030, growing at a significant CAGR from 2022 to 2030. There are several subgroups of genomics: functional genomics, structural genomics, and regulatory genomics.

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Increasing Research Activities Drive Development of Catalog Peptides

Every year, over 9.5 million people die of cancer each year, according to the World Health Organization (WHO). This is because either patients are diagnosed in later stages, or the drugs aren’t able to target tumors that well. A lot of cancers are formed due to the disruption in the pathways activated by peptides, which are essentially short chains of amino acids; a peptide of more than 50 amino acids is known as a protein. Since the establishment of the fact that protein pathway disruption is a potential cause of cancer, extensive research and development (R&D) has been put in to remedy this.

Browse detailed report with COVID-19 impact analysis on Catalog Peptides Market Competitive Landscape

Thus, with the rising prevalence of cancer and fruitful R&D, the catalog peptides market is predicted to grow from $238.4 million in 2018 to $332.1 million by 2024, at a 5.8% CAGR during 2019–2024 (forecast period). The term catalog peptide refers to the artificially synthesized peptide drugs which are readily available with biotechnology and pharmaceutical companies, as opposed to those that are customized as per user preference and the specific application.

Presently, North America makes the largest contribution to the catalog peptides market, owing to the presence of a number of biopharmaceutical companies, increasing R&D investments for widening the application area of such products, and adoption of improved technologies for manufacturing. Within the region, the U.S. consumes such drugs in higher amounts, owing to its increasing incidence of chronic diseases, especially cancer. Moreover, numerous drugs are receiving approvals from the Food and Drug Administration, which is leading to their rising availability for the treatment of various diseases.

Hence, with the rising R&D activities and prevalence of cancer, the demand for catalog peptides will also grow.

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Boom Expected in North America Aromatherapy Market in Future

Because of excessive exposure to pollution and ultraviolet radiation, the prevalence of skin diseases and skin related issues, including reduced elasticity has increased considerably across the globe, including North America. For example, in the U.S., acne is the most common skin condition, and affects up to 50 million Americans each year, according to the American Academy of Dermatology (AAD). One of the more serious skin conditions is skin cancer, and is has been observed that over 9,500 people in the U.S. are diagnosed with this cancer every day. While skin diseases are non-fatal, in most cases, they can considerably affect a person’s mental health, social participation, and ability to function.

Since essential oils have been found to be effective in the treatment of some of the skin conditions, people in North America are increasingly adopting aromatherapy for several purposes. Aromatherapy, also known as essential oil therapy, is a holistic healing treatment which utilizes natural plant extracts for promoting health and well-being. The medicinal use of aromatic essential oils improves both emotional and physical health. While aromatherapy has been around since thousands of years, it has started gaining popularity in the fields of medicine and science in recent times. 

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Aromatherapy is offered by hospitals & clinics, beauty spas, and homes & offices. Beauty spas have been the major contributor to the North American aromatherapy market in the past. The rising disposable income of people in the region is resulting in the growing adoption of aromatherapy for different applications.

Hence, the adoption of aromatherapy in North America is growing due to the rising prevalence of skin diseases and growing disposable income of people.  

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Growing Incidence of Chronic Diseases Powering Medication Adherence System Sales

With the rising incidence of chronic diseases, the sales of medication adherence systems are rising rapidly across the world. Chronic diseases usually require long-term therapies and treatment procedures that involve the utilization of drugs. Any interruptions in drug intake may cause fatal consequences, thereby making strict medication adherence extremely necessary for disease treatment. As per the Centers for Disease Control and Prevention (CDC), in the U.S., 160,201 people lost their lives in 2017 because of chronic lower respiratory diseases.

Chronic diseases are caused because of several factors such as oxidative stress, genetics, and many environmental factors. Clinical intervention is necessary for managing and treating these diseases. This is achieved by increasing the adoption of several patient-centric medication adherence programs. Besides these factors, the growing requirement for medication adherence systems is also boosting their sales across the world. In many countries, the lack of adequate cooperation among patients and healthcare professionals is affecting the quality of patient care.

This is because inadequate cooperation leads to errors in disease diagnosis and the fragmentation of healthcare data and information such as patient demographics, administrative data, billing, and medical history. This makes the usage of advanced medication adherence and management platforms extremely integral for disease management and treatment. Hence, with the growing adoption of these platforms, the global medication adherence market is registering huge expansion. The market valuation will grow from $2,310.0 million in 2019 to $11,226.3 million by 2030.

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Sales of MRI Compatible Patient Monitoring Systems Set to Soar in Asia-Pacific in Future

The increasing number of MRI exams being conducted in several countries is massively pushing up the demand for MRI compatible patient monitoring systems across the world. As per the Annual International Profiles of Health Care Systems Commonwealth Fund published by the Commonwealth Fund, the U.S., France, and Germany were some of the major countries in the world that saw the highest number of MRI exams of people per 1,000 population in 2014.

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According to various reports, there were 114.3, 95.5, and 109.5 MRI exams done per 1,000 people in Germany, France, and the U.S. in 2014. Furthermore, the increasing number of product launches and the surging research and development (R&D) projects and activities in several countries are propelling the demand for MRI compatible patient monitoring systems across the world. Besides these factors, the soaring public awareness about healthcare is also pushing up the demand for MRI compatible patient monitoring systems. 

This is driving the advancement of the global MRI compatible patient monitoring system market. Across the globe, the sales of these systems are predicted to rise sharply in the Asia-Pacific (APAC) region in the coming years. This will be because of the increasing installation of MRI units in the regional countries. As per the Organization for Economic Cooperation and Development (OECD), in Japan, the total number of MRI units per one million citizens was 35.3 in 2002.

This will be a result of various factors such as the surging population of geriatric people, the ballooning usage of technologically advanced and innovative medical systems, and the increasing incidence of several lifestyle-associated and chronic diseases in the region, as per the estimates of P&S Intelligence, a market research company based in India. The MRI compatible patient monitoring system market is also predicted to register huge expansion in Europe in the forthcoming years.

Therefore, it can be said with certainty that the demand for MRI compatible patient monitoring systems will shoot-up all over the world in the future years, mainly because of the rising incidence of various lifestyle-associated and chronic diseases and the increasing number of MRI exams in various countries. 

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What are Major Factors Driving Growth of Nerve Repair and Regeneration Market?

The prevalence of neurological disorders and chronic pain is increasing rapidly at the present time across the globe. Depression, fecal incontinence, epilepsy, Parkinson’s, and Alzheimer’s are the different kinds of neurological disorders. As per the Alzheimer’s Association, about 5.35 million people aged 65 years and above were suffering from Alzheimer’s diseases in the U.S. in 2015. Apart from this, as per the Parkinson’s Diseases Foundation, nearly 60,000 new cases of Parkinson’s disease are reported each year in the U.S. Attributed to these reasons, the demand for efficient medical technologies, such as neuromodulation and neurostimulation devices, is increasing rapidly. 

The different applications of the nerve repair and regeneration devices are stem cell therapy, neurostimulation and neuromodulation surgeries, nerve grafting, and direct nerve repair/neurorrhaphy. Out of these, the largest demand for different nerve repair and regeneration devices was created for neurostimulation and neuromodulation surgeries in the past. Ambulatory surgery centers and hospitals & clinics are the major end users of the nerve repair and regeneration devices. Between these two, the hospitals & clinics category is predicted to witness the fastest growth in the coming years because of the surging patient pool, increasing geriatric population, and improving healthcare infrastructure. 

Access Report Summary - Nerve Repair and Regeneration Market Segmentation Analysis

The potential of stem cell therapy in the field is predicted to create wide opportunities for players operating in the nerve repair and regeneration market. Stem cell therapy is an emerging branch of medicine which has the potential of restoring tissue and /or organ function in patients suffering from critical injuries or chronic diseases. According to clinical research findings, stem cell therapy provides better quality as compared to nerve graft surgeries. Moreover, research is going on in the field of stem cell therapy for its application in the treatment of Alzheimer’s disease and Parkinson’s disease. This is further expected to drive the market in the near future.    

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North America ISOs Medical Device and Equipment Maintenance and Calibration Services Market To Reach $3,612.9 Million by 2030

Factors such as the enhancements in the medical device industry, stringent regulatory norms, and high awareness on preventive medical equipment maintenance will drive the North American independent service organizations (ISOs) medical device and equipment maintenance and calibration services market at an 8.9% CAGR during the forecast period (2021–2030). The market accounted for a $1,468.8-million size in 2019, and it is expected to reach $3,612.9 million by 2030. Currently, the market is witnessing the trend of the adoption of comprehensive contracts among the medical centers in the region.

North America ISOs Medical Device and Equipment Maintenance and Calibration Services Market Revenue Estimation and Forecast

Additionally, the increasing awareness regarding preventive medical equipment maintenance will boost the North American ISOs medical device and equipment maintenance and calibration services market in the future. Medical devices, such as ultrasound systems, X-ray systems, and endoscopes, are used in several clinical applications. These systems require proper and constant maintenance to increase their lifespan. In addition, maintenance and calibration aid in preventing infections due to the usage of such devices on multiple patients. To avoid any unprecedented situation, healthcare facilities are increasingly focusing on the cleanliness of medical equipment and devices.

The automation segment of the North American ISOs medical device and equipment maintenance and calibration services market is bifurcated into automated devices and manual devices. Of these, the automated devices category accounted for the larger market share in 2019, and it is expected to hold its dominance in the forecast years. This can be attributed to the amplifying financial support from the government for medical automation, increasing technological innovations in automation solutions, and fueling need for the accuracy and reproducibility of medical devices and equipment.

Therefore, with the strict government regulations and growing awareness regarding preventive medical equipment maintenance, the market will boom at a high rate in the coming years.

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Disposable Medical Sensors Market Boom to be Led by Asia-Pacific and North America

The global population will increase from 7.7 billion currently to 9.7 billion by 2050, says the United Nations Department for Economic and Social Affairs (UNDESA), in its latest World Population Prospects report. With this, the hold of various chronic and acute diseases on the world is rising, as is of all other issues that can take someone to a doctor. With the growing demand for medical services, the number of hospitals and other healthcare settings is increasing. This is resulting in the surging requirement of various devices, instruments, and systems used at such places, as well as the individual components which make up such stuff, including sensors.

Access Report Summary - Disposable Medical Sensors Market Growth

Therefore, with the rising demand for healthcare, the disposable medical sensors market is advancing around the world. Accelerometers, biosensors, temperature sensors, pressure sensors, image sensors, and several other kinds of sensors are used in medical settings. Among these, the usage of image sensors is expected to increase the fastest in the years to come, because of the burgeoning adoption of complementary metal-oxide semiconductor (CMOS) image sensors with integrated functionality and high-performance attributes.

Due to their wide usage in such diagnostic devices, strip sensors witness the highest demand among all types of sensors, which also include wearable, implantable, invasive, and ingestible sensors. The major reason behind the usage of strip sensors for diagnostic applications is that they carry almost no chance of infections, offer fast results, and are extremely easy to use. Even the elderly can use them on their own, for instance, to test their blood sugar level, for calculating the units of insulin required. In the coming years, the demand for ingestible sensors will witness the sharpest rise, owing to the increasing preference for remote diagnostic imaging and patient monitoring services.

Across the globe, North America procures disposable medical sensors in the highest number, due to the growing investments on research and development (R&D) and rising geriatric population. Additionally, the incidence of HAIs is quite high here, with the Centers for Disease Control and Prevention (CDC) saying that every day, of every 31 hospital patients, one suffers from an HAI. In years to come, the disposable medical sensors market will grow the fastest in Asia-Pacific (APAC), with the rising chronic disease prevalence and geriatric population, R&D funding, and government initiatives.

Hence, as more medical settings are constructed to cater to the mushrooming patient pool, the same of disposable medical sensors will increase too.

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Hospital-Acquired Infections Boosting Usage of Single-Use NPWT Devices

Wounds are perhaps the most-common form in which an injury is visible. They can range from minor scrapes and cuts to those that tear the flesh and expose the bone. While nothing normally needs to be done for minor wounds, the major ones don’t heal as quickly on their own. Moreover, unhealed wounds accumulate pus and ultimately become a breeding ground for microbes, which can lead to gangrene, requiring the entire affected tissue to be removed. In extreme cases, gangrene results in limb and arm amputations.

Access Detailed Report - Single-Use Negative Pressure Wound Therapy Devices Market Revenue Estimation

As a result of the growing awareness on the dangers of open wounds, P&S Intelligence predicts the single-use negative-pressure wound therapy (NPWT) devices market revenue to reach $1,673.1 million by 2030 from $770.2 million in 2020, at an 8.1% CAGR between 2020 and 2030. This is because since the 1990s, NPWT has become a preferred advanced wound care solution, especially for long-lasting wounds. The term ‘negative pressure’ implies that unlike conventional wound healing techniques, it doesn’t press on the wound; rather pulls at it, thereby sucking out the exudate.

In regards to single-use NPWT, it is the surging cases of hospital-acquired infections (HAIs) that are propelling their usage. As conventional variants are used on multiple patients, they can easily transmit infections from one patient to another, many of them deadly ones. The World Health Organization (WHO) says that “Of every 100 hospitalized patients at any given time, 7 in developed and 10 in developing countries will acquire at least one health care-associated infection.”. This not only leads to a high mortality burden, but it can also lead to millions in losses for healthcare settings if the allegations of negligence are proved.

Hence, North America is the largest single-use NPWT devices market in the world, because not only is its healthcare infrastructure highly advanced, but the regulations on HAI prevention are also among the strongest here. Moreover, the continent has a high incidence of chronic diseases that cause wounds on their own or as a result of surgeries. Similarly, Asia-Pacific (APAC) is embracing this technique with the increasing investments in its healthcare sector, rising burden of diseases, and an already-high incidence of burns and road accidents.

Hence, with the advancing medical sector, the adoption of single-use NPWT devices will grow.

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Cover Corona Outbreak Impact: Respiratory Diagnostic and Monitoring Device Market is expected to Boom in Coming Years

The growth of the market is attributed to the increasing geriatric population, prevalence of respiratory disease and smoking, pollution level, healthcare expenditure, and rapid urbanization. Respiratory diagnostic and monitoring devices provide monitoring and diagnostic evaluation of cardiopulmonary system disorders and diseases. These devices are used extensively in intensive care units, general and surgical wards, and homes.

On the basis of type, the respiratory diagnostic and monitoring device market is divided into gas analyzer, capnograph, spirometer, pulse oximeter, and others. In 2015, pulse oximeters held the largest share of the market, and the division is expected to grow at the highest CAGR during the forecast period as well. Pulse oximeter, a non-invasive instrument, is used to measure the proportion of oxygenated hemoglobin in the blood, and it also enables the measurement of the pulse rate.

The increasing pollution level and rapid urbanization are leading to the growth of the respiratory diagnostic and monitoring device market. The lifestyle associated with urbanization is threatening the health of individuals. Furthermore, air pollution is having a considerable effect on the respiratory health and also leading to climate change. The fine particles emitted by motor vehicles, industries, and houses are responsible for a range of cardiovascular conditions, respiratory diseases, and cancers. In addition to this, the urban lifestyle results in an increase in the prevalence of chronic diseases and consumption of unhealthy food.

Hence, emerging economies are a potential area for the growth of the worldwide healthcare industry. Moreover, the rising prevalence of respiratory diseases, rapid urbanization, and increasing pollution level are driving the growth of the market for respiratory diagnostic and monitoring devices.

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Why Is Geriatric Population Boom a Key Surgical Simulation Market Driver?

The surgical simulation market is expanding on account of the increasing surgery volume, booming geriatric population, rising popularity of minimally invasive surgeries, and rapid technological advancements. Thus, the revenue generated from the sale of such solutions, which was $337.4 million in 2019, is predicted to display a healthy 16.4% CAGR between 2020 and 2030 (forecast period). Such simulators create virtual representations of real-life medical situations, so that students, as well as experienced doctors, can practice their skills.

The divisions on the basis of end user are hospitals, academic & research institutes, military organizations, surgical clinics, and others, which include nursing homes and fertility centers. In 2019, the highest market revenue was generated by the academic & research institutes division, as students are now demanding a first-hand training experience, before they operate on real patients. Moreover, even professionals are using simulators to improve their skills, as new medical procedures are being innovated. Even during the forecast period, this division is expected to witness the fastest advance in the industry.

Another key driver for the surgical simulation market is the booming geriatric population. The United Nations Department of Economic and Social Affairs (UNDESA) says that by 2050, the population of people in the 65-and-above age group will rise to 1.5 billion, from 703 million in 2019. The elderly suffer from more-serious diseases more often, which creates a need for long-term medical care. Therefore, the hospitalization rate, surgery volume, and chances of surgical complications in the elderly are higher, thus leading to the rapid adoption of surgical simulators.

Asia-Pacific (APAC) is projected to advance the most rapidly in the surgical simulation market during the forecast period. The geriatric population is increasing in the region, with the UN predicting the number of elderly people in India and China to reach 324 million and 437 million, respectively, by 2050. Moreover, medical procedures in the regional developing countries are cheaper than in developed countries, which is why hordes of people from the latter come to the former for treatment, thereby resulting in the increasing adoption of surgical simulation solutions for training.

Hence, as the volume of surgeries and number of older people increase around the world, so will the demand for surgical simulators for first-hand training.

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Skin Replacement and Substitutes Market to Witness Robust Growth in Coming Years

 Over 180,000 people are burned to death every year, the World Health Organization (WHO) had estimated in 2018. Additionally, burns are the leading cause of disability-adjusted life years (DALY) in low- and middle-income countries. Such incidents often lead to nasty scars, as the skin peels or melts. In severe cases, the skin is damaged so much that it is unable to heal or grow back on its own, which results in skin grafting procedures.

Thus, with the increasing incidence of burn injuries, the skin replacement and substitutes market, which valued $838.0 million in 2018, is predicted to grow to $1,202.2 million by 2024, at a CAGR of 6.3% during 2019–2024 (forecast period). The usage of such products helps close and mend the wound as well as reduce the pain, which is why they are witnessing a rising adoption around the world. There are two primary types of skin replacement and substitute products available — cellular and acellular — of which the acellular variants are more in demand, as they can be used for excised and superficial wounds, even in pediatric patients. 

All the cellular and acellular products are further segregated as class I, II, and III. Of these, class III products account for the widest adoption, as they can effectively mend the dermis as well as the epidermis, which makes them suitable for ulcers, burns, and numerous other kinds of wounds. Ulcers, in particular, can result in the loss of the entire epidermal layer, as well as the dermal layer and subcutaneous fat, in severe cases. If left untreated, skin ulcers can morph into full-blown gangrene, the treatment for which is amputation, which is why an increasing number of people are seeking treatment for them. 

Another reason for the rising demand for such products is the growing disposable income of people around the world. According to the World Bank, the worldwide gross domestic product (GDP) per capita surged from $8,820.013 in 2009 to $11,312.555 in 2018. This rising purchasing power is enabling people to spend more on their appearance, which is why they are rapidly going for dermatological treatments, even if they are lot life-threatening, thereby leading to the surging demand for skin replacement and substitute products. 

Therefore, with more people suffering from burns and skin diseases, the demand for products which help treat the wounds will also increase. 

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How is Booming Life Sciences Sector Contributing to Growth of Pulse and Regional Oximeters Market?

Every year, 250,000 people die in the U.S. due to medical errors, as per a 2018 report published by the Johns Hopkins University. These not only impact patients and their relatives, but also hospitals, in the form of allegations of medical malpractice and ignorance. Other factors responsible for in-patient deaths are the severity of patients’ condition, underdeveloped healthcare infrastructure, primarily in emerging economies, and inadequately trained professionals. This is why, the demand for advanced medical devices is increasing across the globe, so doctors can better monitor patients. One of the most essential equipment at healthcare settings is an oximeter.

Further, these devices help determine whether supplemental oxygen is needed and also monitor the saturation under anesthetization. This is why, the use of such instruments has become a mandate, and governments of various countries are taking steps to ensure compliance. For instance, Masimo Foundation and Koninklijke Philips N.V collaborated with the Ethiopian government, in April 2016, to provide healthcare professionals in the nation with regional and pulse oximeters, especially for children and women. Later, the initiative was expanded to other countries in Sub-Saharan Africa and numerous in South Asia, where a large number of neonatal, pediatric, and maternal deaths are reported.

Around the world, North America has witnessed the widest use of these instruments, as several established companies are headquartered here, healthcare infrastructure here is more advanced than in other regions, and the geriatric population is rapidly growing. During the forecast period, the pulse and regional oximeters market growth in Asia-Pacific (APAC) would be the fastest, owing to the keen interest of device manufacturers to enter the regional market as well as the improvements in the healthcare infrastructure.

Hence, with SpO2 monitoring becoming mandatory in more countries than before and the prevalence of various chronic diseases increasing, oximeters would find an even wider application in the coming years.

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How is Rising Use of mHealth Driving North American Patient Engagement Solutions Market?

The ballooning usage of mobile health solutions is pushing up the requirement for healthcare apps. Moreover, these solutions are fueling the surging adoption of e-prescriptions and electronic health records (EHR), that use cloud for storing health data. Because of this reason, the growing usage of mobile health solutions is positively impacting the demand for cloud-based patient engagement solutions in North America. As per a study conducted by the Pew Research Center, around 77% of Americans are smartphone users.

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The increasing population of geriatric people is pushing up the requirement for technologically advanced healthcare and medical solutions, on account of the fact that the geriatric people are highly vulnerable to various chronic diseases and are usually not able to travel frequently for medical treatment. Cloud-based patient engagement solutions are allowing them to seek healthcare and remain connected with medical practitioners at all times without physically traveling to the healthcare facilities. 

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As per the 2017 World Aging Population report produced by the United Nations Department of Economic and Social Affairs (UNDESA), the population of people in the age bracket- 60 years or above in the U.S. was 69.7 million in 2017. Moreover, as per the report, this number is predicted to increase to 108.4 million by 2050. This will massively boost the demand for patient engagement solutions in the country in the coming years. 

Web-based, cloud-based, and on-premises are the main three types of methods via which the patient engagement solutions are deployed in the region. Out of these, the usage of web-based delivery mode is predicted to be the highest in the forthcoming years. This would be because the web-based delivery mode can be easily accessed both offline and online, unlike the cloud-based one, which requires the availability of high-speed internet for access. 

The North American patient engagement solutions market recorded the highest growth in the U.S. in the years gone by and this trend is predicted to continue in the upcoming years as well. The rapid market advancement in the country will be driven by the existence of advanced and well-established healthcare infrastructure, the increasing presence of numerous healthcare IT solution providing organizations, and the growing incidence of chronic diseases in the country.

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What are Key Factors Driving the Growth of Medical Equipment Maintenance Market?

 The market growth is propelled by the improvements in medical devices, rise in the awareness regarding preventive maintenance, and stringent regulatory ecosystem. At present, end users are entering into multi-vendor contracts to reduce the complexities and additional expenses related to different services offered under individual agreements with the producers of medical equipment.

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One of the key growth drivers for the medical equipment maintenance market is the advancements in the medical device industry. Manufacturers of medical equipment are developing an array of high-quality products by using innovative technologies, on account of the heavy investments in research and development (R&D) activities. Medical devices have a certain life expectancy and need maintenance or replacement after a certain time. Thus, the expansion of the medical device industry will boost the market growth during the forecast period.

Another factor supporting the medical equipment maintenance market growth is the rising awareness regarding preventive medical equipment maintenance. Healthcare facilities are emphasizing cleanliness due to the guidelines laid down by international organizations to prevent infections and improve the cleanliness regimen. For example, as per the hospital hygiene and infection control guidelines of the World Health Organization (WHO), hospitals must focus on equipment management. Due to this, healthcare facilities are adopting numerous types of maintenance services for various medical devices.

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Moreover, the Asia-Pacific medical equipment maintenance market is projected to exhibit the fastest growth during the forecast period. This market is stimulated by the rising number of diagnostic tests in the region and increasing incidence of chronic ailments, which need medical devices for early diagnosis. Moreover, the rapid rise in the number of hospitals in the region, especially in China, will drive the market growth in the future. The number of hospitals in China increased from 27,600 in 2015 to nearly 33,000 in 2019.

Thus, the largescale construction of hospitals, rapid installation of advanced medical equipment, and increasing awareness regarding preventive medical equipment maintenance will fuel the market growth in the coming years.

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